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1m), which is important as these mice have low levels of endogenous mouse IgG due to lack of binding to the human receptor 30,31,32

Glutathione levels decline with age and are depleted by oxidative stress

While NP4 remained relatively stable under physiological conditions, the payload was readily released in the presence of H 2 O 2 (Supplementary Fig

From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models

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