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Obesity increases the prevalence of asthma [5] and individuals that are obese account for the majority of severe or difficult-to-control asthma cases in the US [6]

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Synergy with immune checkpoint blockade In situ cancer vaccination primes broad, patient-specific T-cell responses by releasing diverse tumor antigens and activating antigen-presenting cells, but the efficacy is often limited by immune checkpoints such as PD-1/PD-L1 and CTLA-4 that suppress CTL activity within the TME

This feedback typically becomes available during the summer in between the performance period and the MIPS payment year, which is as soon as feasible