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What monitoring is necessary (ECG, labs) during initiation

Proceedings of the Royal Society of London 77(519):405-420. [doi.org]

It typically peaks during dose escalation and resolves within 1-2 weeks at each new dose level

Chevaisrakul P, Lumjiaktase P, Kietdumrongwong P, Chuatrisorn I, Chatsangjaroen P, Phanuphak N

mRNA expression analysis by real-time PCR Total RNA was isolated from the dissected tissues using the RNeasy Mini kit (Qiagen, CA, USA), followed by reverse transcription using the High Capacity RNA-to-cDNA kit (Thermo Fisher Scientific, Waltham, MA, USA) according to the manufacturers instructions

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