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In one study called TIPO-1, participants were given different doses of tesofensine or a placebo along with a reduced-calorie diet for 24 weeks

Two studies using high throughput screening discovered active compounds with IC50 in the nanomolar range [78-79]

This is a clinical-level guide synthesizing findings from primary scientific literature to provide a definitive resource for the bio-hacker, clinician, and advanced user

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Certain groupsincluding vegetarians, older adults, and those with medical conditions affecting absorptionare at greater risk for deficiency

They are two different classes of molecule with two different mechanisms and two different evidence trails, one of which happens to include a body of human physiological data the other simply doesnt have, owing entirely to the fact that one of them is something the body already makes