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replacement of the aromatic residues Phe, Tyr, and Trp, and replacement of the small-sized amino acids Ala, Ser, Thr, Met, and Gly

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Moreover, they regulate the neurotransmitter release by controlling the amount of glutamate that reaches the presynaptic receptors

Conversely, the explicit anti-apoptotic effect of NSO in renal tissue observed in the present study was confirmed with normalized caspase-3 and caspase-9, supported by previous research reporting that nephrotoxicity caused by sodium nitrite was decreased by NSO via reducing inflammation, fibrosis, and oxidative stress, and inhibiting apoptosis by suppressing caspase-3 and pJNK/JNK (97)

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