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This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24

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AOD-9604 is available in Canada as a 5 mg research vial from suppliers like Red Fox Peptides, priced at $55 CAD with shipping from British Columbia

The authors also suggested that targeting amino acid metabolic pathways could be helpful in developing adjunctive therapies (Pahwa et al., 2024)