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Similarly, the stimulatory effect of GH on eel spermatogenesis is not dependent on IGF-I and steroid [28]

It activates the GHRH receptor via cAMP/PKA and, per Alba et al., increases GH mRNA and somatotroph proliferation

This led to speculation that GHS was releasing a heretofore unknown factor (U factor) from the brain 5

It was developed to isolate the fat-metabolizing activity of hGH while eliminating the growth-promoting, diabetogenic, and IGF-1 stimulating effects associated with full-length growth hormone administration

All recommendations prioritize regulatory transparency, patient safety, and individualized assessment rather than unapproved therapeutic claims

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