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Furthermore, obesity would lead to ventricular remodeling and dysfunction, which destroy the structure and physiological function of the heart, and eventually lead to heart failure (32)

Contrary to claudin-1, which in normal colonic epithelial cells is expressed to a minimum (even though it is highly increased in colon cancer tissue and cells 65 ), the claudin-7 protein is highly expressed in the colonic epithelium

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Khan K.A., Kerbel R

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This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)