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Reactive oxygen species was involved in central sensitization caused by decreased presynaptic inhibitory transmission and decreased synaptic -aminobutyric acid(GABA) release in the spinal cord

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Furthermore, the neurotransmission decrease conducts to an excess of neuro-inhibition, which contributes to encephalopathy

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10.1016/j.neurobiolaging.2013.06.024 28 CarpenterD.HsiangC.JiangX.OsorioN.JonesC.WechslerS

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