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The gap between molecular data and clinical outcomes remains significant

Together, these data demonstrate that intracellular GSH depletion synergizes with the APP Swe/Ind mutation to promote ferroptosis in SH-SY5Y cells

10.1016/j.cell.2007.06.009 Cell 42 ManningB

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These effects were contributed to benfotiamine's action on transcription factors NF-B and Egr-1, arachidonic acid pathway, protein kinase C and members of MAPK signaling cascade p38, ERK1/2, SAPK/JNK [14,15]

Standard corneal transplantation with mechanically tough human donor tissue often results in scar tissue formation at host-to-implant interfaces 50,60 , a phenomenon we did not observe with the mechanically softer BPCDX