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Within inflammatory and tumor microenvironments, these dying cells play a significant immunomodulatory role by interacting with immune cells, particularly dendritic cells and T cells, present in the surrounding environment 117,118,119

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Once inside, the unprotonated amphetamine molecules become rapidly protonated by the acidic environment of the vesicle, which alkalinizes the vesicle matrix and completely dissipates the necessary pH gradient (Wimalasena 2011)(see Figure 2 Mechanism A)

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The median (interquartile range) ALT and qHBsAg at EOT were 23.0 (18.0-31.0) U/L and 104.5 (30.8-616.0) IU/ml respectively

Clinical patterns: Findings such as early greying may reflect oxidative stress but are considered observational rather than diagnostic