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The dose volume was calculated for individual animals on the first day of treatment and was re-calculated according to the most recent body weights recorded during the treatment period

Consistently, the study by Tang et al

Osteo-Inductive Models Bone homeostasis is maintained by a delicate balance between bone-forming osteoblasts and bone-resorbing osteoclasts

Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis

The levels of oxidized proteins decreased in ibuprofen treated male livers compared to controls, while not significant, a trend towards the increase in levels of oxidized proteins (P = 0.086) was observed in ibuprofen-treated female livers relative to controls

Fagone, P