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The apoptosis induction, which is characterized by DNA condensation, cytoplasmic histone-associated DNA fragmentation, and cleavage of PARP, was connected with the withaferin A -mediated suppression of breast cancer cell survival ( In vivo MDA-MB-231 xenograft suppression by withaferin A is accompanied by decreased cellular proliferation and enhanced apoptosis by FOXO3a and Bim (Stan et al., 2008b)

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