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Studies in Ewings sarcoma cells treated with figitumumab, an IGF-IR antagonist, revealed that this antibody functioned as an IGF-1R-biased agonist through -arrestin1 recruitment to the receptor, enhancing IGF-IR ubiquination and provoking Erk phosphorylation in the absence of Akt activation (92)

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Indian J Pharmacol 40(1):2831 Agusti A, Fabbri LM, Singh D, Vestbo J, Celli B, Franssen FM, Franssen FME, Rabe KF, Papi A (2018) Inhaled corticosteroids in COPD: friend or foe

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doi: 10.1016/j.dsx.2023.102896 67 ZhangZLiuQHuangCWuJWenY