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In various types of cancers, including gastric (5), lung (27), breast (17,28), endometrial (29), cervical (30), prostate (31) and head and neck tumors (21), the downregulation or complete silencing of GPX3 gene expression, along with hypermethylation of CpG in the CpG island of the GPX3 promoter, have been observed (32)

Subpopulations may survive high drug concentrations through stress response pathways, while dormant phenotypes persist within host niches like macrophages ( Candida auris and Rhodosporidiobolus fluvialis , underscores the urgency for new therapeutic approaches (Jackson et al., 2019