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22 Among flavonoids, 6-C-(E-phenylethenyl)naringenin (6-CEPN) is a semi-natural derivative of naringenin (chemically synthesized by modifying the naturally occurring naringenin to enhance its bioactivity), a flavonoid commonly found in citrus fruits and other plants

To view a copy of this licence, visit About this article Cite this article Ahmad, N., Lesa, K.N., Ikawati, Z

P., & Calder, P

Recent study demonstrated that triptolide directly affects the tumor microenvironment by selectively depleting TAMs, inhibiting the function of M2 macrophage differentiation and viability, and suppressing M2 marker expression and anti-inflammatory cytokine secretion, leading to reduced tumor burden in experimental models of cancer [969, 970]

When approximately 60 to 80% of the dopamine-producing cells are damaged and do not produce enough dopamine, the motor symptoms of Parkinsons disease appear [68]

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