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Recent studies have shown IL-33 to be upregulated in epithelial cells and myofibroblasts in UC ( So far, most of these cytokines and chemokines have been studied more in mechanistic contexts than as clinical biomarkers

Crum Y, van Veldhuisen DJ, Shah SJ, Mylavarapu U, Hu M, Komtebedde J, Lobeek M, Hoendermis ES, Litwin SE, Solomon SD, Cutlip DE, Leon MB, Kaye D, Bruch L, Seidler T, Cikes M, Mohan R , Lilly S, Collins N, Emani S, Chetcuti S, Bugger H, Kotlyar E, Reed GW, Gordon R, Gupta DK, Borlaug BA, Gorter TM

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Although the cell death mechanism of RPE, which is susceptible to oxidative stress, remains controversial, ferroptosis has been recently recognized as a primary mode of RPE cell death (81)

The obsession with the bell curve deal with not only how people tend to see things, but also want to see the world

10.1084/jem.20192282 J