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Further study is required to elucidate this possibility in vivo

Additionally, the study assessed weight and metabolic responses, finding that efinopegdutides tolerability was similar to that of semaglutide, although certain gastrointestinal side effects were more common

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Disclosures: Mengya Zang: Nothing to Disclose, Peilin Zhu: Nothing to Disclose, Qingxian Cai: Nothing to Disclose, Haojie Liao: Nothing to Disclose, Dayong Zheng: Nothing to Disclose, Feng Shi: Nothing to Disclose, Hualang Cai: Nothing to Disclose, Xuan Wu: Nothing to Disclose, QI Li: Nothing to Disclose, Huajin Pang: Nothing to Disclose 1809 THE HIPPO PATHWAY EFFECTOR TAZ IS REQUIRED FOR NOTCH-DRIVEN CHOLANGIOCARCINOGENESIS VIA METTL3-MEDIATED M6A MODIFICATION Wenbo Ma 1 Jinqiang Zhang 2 Weina Chen 1 Nianli Liu 2 Tong Wu 3 , 1 Tulane University School of Medicine, 2 Tulane University, 3 Tulane Medical Center Background: Notch and TAZ are implicated in cholangiocarcinogenesis, but whether and how these oncogenic molecules interact remain unknown