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J Exp Med 69(4):507516 Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, Stojanovska L (2021) Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19

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Protein modifications by acrolein induce ferroptosis Acrolein irreversibly modifies proteins by forming covalent adducts with nucleophilic residues, such as cysteine, histidine, and lysine, significantly altering their structure and function, and potentially leading to cell death 57

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Therefore, interventions that sustain D-serine levels or NMDA signaling might improve neural reinnervation in older adults