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The pathological effects of oxidative stress underscore the importance of developing therapeutic strategies aimed at reducing ROS levels and enhancing antioxidant defenses to improve male fertility outcomes

Notably, the glutathione S-transferase proteins represent an extended family of multifunctional enzymes that are involved in diverse pathways such as oxidative stress response, and detoxification of various substrates 28

This should be considered in individuals with diabetes or those at risk of hypoglycemia

HK2-OE resulted in a significant decrease in ROS production and apoptosis in HL-1 cardiomyocytes

It selectively targets fungal mitochondrial complexes, blocking electron transport and disrupting the proton gradient across the inner membrane

Toll-like receptors as a therapeutic target in the era of immunotherapies