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Along these lines, our quantitative proteomic analysis of protein abundance revealed a prominent reduction in abundance of all subunits of hemoglobin in tumor tissue (Supplementary Data 2, 5) as well as a reduction in proteins responsible for maintaining proper lung function and integrity of the epithelial barrier, such as claudins 28 (claudin-18), caveolins (CAV1 and 2) 29 , angiotensin-converting enzyme (ACE1 and 2) 30 and others (Suppl

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