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Cells were incubated with LicoA (or vehicle control) and subsequently subjected to heating across a temperature gradient (37.0 C65.0 C)

Scalera et al., 2009)

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Key mechanisms include the livers role in clearing peripheral -amyloid (A), the influence of hepatic enzymes and metabolites on cognitive decline, and the systemic effects of metabolic disorders on AD progression

Regarding the in vivo variation in the SASP, the expression of TNF- and MMP13 was also significantly increased in the vehicle group, accompanied by decreased expression of aggrecan, demonstrating disruption of IVD homeostasis

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