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Warner JB, et al

In: Yadav AN, Rastegari AA, Yadav N, Kour D (eds) Advances in plant Microbiome and sustainable agriculture: diversity and biotechnological applications

The Nature Scientific Reports 2016 study confirmed that GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers

Rather, mice with the highest plasma concentrations of TMAO had the most plaque at the aortic root, whereas those with suppressed gut microbes and lacking TMA/TMAO showed no increase in atherosclerosis