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These receptors are found on mitochondria in activated microglia and some neurons (Banati 2002) but ligand binding is increased when glia are activated

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Why the dose schedule cannot be rushed Clinical trial data from the phase 2 NEJM study revealed something critical about dose scheduling

Arnao MB, Cano A, Hernandez-Ruiz J, Garcia-Canovas F, Acosta M

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Only exons from major isoforms with an initial exon exceeding 100 base pairs were considered, while isoforms annotated as single-exon were excluded