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Copper peptides such as GHK-Cu have been associated with upregulation of TGF-beta in dermal fibroblasts and with stimulation of type I and type III collagen

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In puppies younger than 11 weeks of age, histological evidence of bone marrow hypocellularity was observed at higher frequency and greater severity in puppies treated with CERENIA compared to control puppies

[3] [16] However, patients occasionally report experiencing muscle cramps, including in the legs, during treatment, and several indirect mechanisms may explain this phenomenon

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