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The disease can present with symptoms affecting multiple systems, including lethargy, vomiting, shortness of breath, symptoms of metabolic acidosis, developmental delay, epilepsy, etc

Mitochondria are organelles of the cell that are primarily responsible for oxidative phosphorylation, the production of intracellular energy from oxygen and nutrients, as well as heme synthesis (82) and assembly of eukaryotic iron-sulfur (Fe-S) protein clusters (83)

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