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May Be Useful In Reducing Side Effects Of Cancer Treatments A 2021 in vivo study found that FOXO4-DRI was able to lower the incidence of senescence induced by radiotherapy: Specific induction of senescence-like [cancer-associated fibroblast] apoptosis using FOXO4-DRI, a FOXO4-p53interfering peptide, resulted in remarkable effects on radiosensitizing NSCLC cells in vitro and in vivo