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Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Its primary role is that of a shuttle: it helps certain fatty acids enter the mitochondria, where they can be used to produce energy

30 , representing genes negatively regulated in the fibroblast core serum response, was also strongly enriched among the genes upregulated by GSTO1 knockdown (Fig

A study using fluorogenic peptide substrates found that caspase-4, -5 and -11 substrate specificity for GSDMD is influenced by prime side amino acids P1- P4, while caspase-1 substrate affinity is mostly influenced by the P1-P4 sequence ( GSDMD processing involves its cleavage after the aspartic acid residue 276 (Shi et al., 2015b)

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