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Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium

These peptides are currently heavily utilized in wellness, longevity, and restorative medicine but have faced regulatory uncertainty regarding their safety and legality

**The FDA does not review or approve any compounded medications for safety or effectiveness

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