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10.3389/fphar.2021.813587 118 YangY

Once in circulation, it activates two receptors that the gut normally talks to after a meal: GIP and GLP-1

[827] Outcomes for individuals with SUDs are improved through early and regular treatment

PPAR- is well-known for its strong influence in inducing an M2 phenotype in macrophages, PPAR- activation leads to increased expression of genes associated with fatty acid storage and glucose metabolism, which are vital for the functioning of M2 macrophages (261, 262)