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p53 inhibits ASNS expression by binding to the asparagine synthase (ASNS) gene, decreasing the Asp-Asn ratio, and direct binding of Asp to LKB1 activates AMPK while leading to higher activation of p53 [103]

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doi: 10.3389/fcell.2022.976953 Received 23 June 2022 Accepted 18 July 2022 Published 10 August 2022 Volume 10 - 2022 Edited by Xinjian Zhu, Southeast University, China Reviewed by Nyzil Massey, Iowa State University, United States Manikandan Samidurai, Iowa State University, United States Updates Copyright 2022 Fabisiak and Patel

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