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Beyond these classical mechanisms, bilirubin may fundamentally shape PD risk by orchestrating early embryonic development of dopaminergic neurons through key morphogenic signals, thereby ensuring robust neural circuit formation

PMID 34942066

Free Radical Biol Med 20:331342 van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A, Slama-Schwok A, Shiva S, Vanin AV, Weitzberg E, Zweier J, Gladwin MT (2009) Nitrite as regulator of hypoxic signaling in mammalian physiology

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5 Treatment challenges and therapeutic innovations Despite being the cornerstone of symptomatic management, current Parkinsons disease (PD) treatments are palliative rather than disease-modifying

Similar to recent studies on dual ferroptosis inducers, the dual-targeting strategy is consistent with the emerging paradigm of combinatorial targeting to overcome compensatory mechanisms