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After activation, the Wnt/-catenin pathway causes -catenin to become stable and move to the nucleus, where it uses T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) transcription factors to activate and control downstream target genes, ultimately increasing the expression of genes related to cell migration, differentiation, proliferation, and survival (198, 199)

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Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

17 It can improve inflammation in the musculoskeletal system, brain, and gastrointestinal tract, targeting multiple body systems impacted by Lyme and other tick borne diseases