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Lancet Diabetes Endocrinol 2022;10:193206.ArticlePubMed 50

Structure of the MDM2 RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

Wiegand et al., 1986)

Liposome flotation assays with plasma-membranederived lipids confirmed that M105I directly impairs lipid binding and that membrane composition influences this interaction

During hypoxia-reperfusion cycles, ROS production increases, overwhelming the antioxidant defense system and promoting ferroptosis in trophoblast cells (Figure 1