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Additionally, when intracellular iron levels decline, ferritin is degraded to release free irona process termed ferritinophagy

PI3Ks are involved in a wide range of intracellular regulatory mechanisms, and their functional deregulation has been associated with a variety of human diseases (230)

In this process, 10 L of the ITC was mixed with 25 mg of lysine in 10 mL of water:ethanol (1:1, pH = 10) at room temperature for 24 h

*Correspondence: Xiaoyuan Zheng, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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