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TQ also in a dose-dependent manner inhibits COX and lipoxygenase (LOX) enzyme activities, consequently blocking the synthesis of inflammatory mediators, prostaglandins, thromboxane, and leukotrienes and reducing joint inflammation (262)

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Administration of the GLS1-specific inhibitors BPTES and CB-839 reduced keratinocyte proliferation and chemokine production, decreased Th17 and Th17-cell differentiation and epidermal proliferation, and improved the splenomegaly and skin lesions in a psoriasis-like mouse model (79)

Afterwards, the cells were filtered through a cell strainer and analyzed using a flow cytometer (FACS Verse, Becton Dickinson) with a 488 nm laser for excitation and BD FACSuite Software v1.0.6 (Becton Dickinson)

doi: 10.3390/nu16091298

Recent research found that Kaempferol suppresses CCl-induced liver fibrosis progression by restoring GM diversity, reducing the relative abundance of Faecalibaculum and Bifidobacterium, while increasing that of Lactobacillus, Bacteroides, and Allobaculum, and elevating SCFAs levels in the gut and liver, thereby activating the Nrf2 signaling pathway to reduce oxidative damage [234]