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Reductions in catalase levels at both the mRNA and protein levels in the bronchiolar epithelium of smokers with COPD highlight a correlation between decreased bronchiolar catalase and COPD development, with the regulation of catalase being crucial in preventing cell damage induced by cigarette smoke exposure [118]

Peroxynitrite may reach mitochondria either from extramitochondrial compartments or may be directly produced within the mitochondria

Diabetics are particularly susceptible to excessive AGE accumulation due to chronic blood sugar elevation

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