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doi: 10.1056/NEJM196801112780203 43 NiiharaY.MillerS

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

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Clinical severity was graded as 0 (normal), 0.5 (erythema and edema in only one digit), 1 (erythema and mild edema of the footpad, or ankle or two to five digits), 2 (erythema and moderate edema of two joints [footpad or ankle, two to five digits]), 3 (erythema and severe edema of the entire paw), or 4 (reduced swelling and deformation leading to incapacitated limb) 68

The results revealed that there was a similar pattern of PCNA induction by administration of BPC 157 and growth hormone, that correlated with the increase in the number of viable cells [2]