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Although rare, gallbladder cancer can be considered as a highly fatal complication of gallstones, since the tumour has a high grade of malignancy and diagnosis is often delayed, despite that it is an incidentaloma in 12% of cases during cholecystectomy [170, 171]

Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study

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Indeed, a broad spectrum of studies supports the multiple anticarcinogenic properties of plant-derived polyphenols, including their inhibitory effects on the proliferation of cancer cells, tumor expansion, angiogenesis, inflammation, and metastasis whereas some studies show potential synergistic effects when polyphenol treatment combined with chemotherapeutic agents [33]

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