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Some cell types, among which the energy-ravenous and stress-sensitive brain neurons, cannot synthesize glutathione endogenously and rely on import from neighboring cells of the glia

GSH is the most important antioxidant and free radical scavenger that is found to be decreased in the brains of people with a wide range of mental and neurological illnesses from schizophrenia[iv] to dementia[v] [vi]

Happle and Kster were unable to demonstrate a bimodal distribution of phenotypes with clearly unaffected and clearly affected individuals as is usually seen in autosomal dominant disorders (51)

We conclude that the main function of endogenous GSH is not to limit inflammation but to fine-tune the innate immune response to infection

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FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology vol