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This lesion is much less likely to be preneoplastic and a few toxins have been shown to induce the lesion

This is the basis for oral and capsule research formats, especially in gut-focused models

Aug 2016;30(4):733-56

Maximal effects typically occur at four to six weeks, with full tissue remodeling continuing over three to six months

In summary, disruptions in FA metabolism mediated by astrocyte mitochondria dysfunction may contribute to the pathogenesis and progression of PD, highlighting potential targets for therapeutic interventions

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