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This metabolic shift enables MDSCs to sustainably generate energy in hypoxic environments, while concurrently mitigating ROS production and subsequent apoptosis, thereby safeguarding their survival and functionality (110, 112).Chiu et al

Cell 151 , 253266 (2012)

These cardiovascular adverse effects include first-dose bradycardia, atrioventricular conduction block and hypotension, and they must be cautiously considered when utilizing this drug for CIPN prevention and treatment [4]

Alcohol Clin Exp Res 20(8):13521361 Zhang Z et al (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

It plays a vital role in the healthy functioning of many systems in the body, including the following: DNA (genetic material) synthesis Energy production (metabolism) Nerve cell health Neurological (brain) function Red blood cell (hemoglobin) formation Vitamin B12 plays a key role in the normal functioning of the brain and nervous system

The underlying disease mechanisms include immune activation, mitochondrial dysfunction, lipid homeostasis disorder, and metal ion imbalance (Tolosa et al., 2006