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The data showed that 3T3-L1A-EV treatment did not affect glycolysis (Fig

62: 10023 Mercieca JE, Clarke MF, Phillips ME, et al

In the presence of l-arginine and cofactor BH4, electrons can reduce O 2 to form NO and l-citrulline ( 2 , thus forming instead of NO, a process defined as eNOS uncoupling (47, 48)

A new successful systemic treatment is immunotherapy with immune checkpoint inhibitors, but new tumor-specific biomarkers are needed to improve patient outcomes