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doi: 10.1073/pnas.2003909117 137

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87 Studies have also shown that hypoxia promotes the development of ferroptosis by activating HIFs, which induce the increased expression of lipid-related proteins and drive the enrichment of polyunsaturated lipids to induce ferroptosis

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Importantly, M1/M2 macrophage polarization has been associated with the progression of fibrotic diseases [23, 24]