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Patients with ESCC often suffer from deficiencies of these micronutrients due to reduced intake and metabolic disturbances, leading to impaired function of immune cells (especially T cells and macrophages) and a decreased ability to clear pathogens, thereby significantly increasing the risk of postoperative infectious complications such as pneumonia (3538)

Experimental, TR receptor knockout (KO-TR) mice exhibit decreased body temperature, decreased basal metabolic rate, growth retardation, and increased adipose tissue [78]