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GPX4 is a key regulator of the classical pathway of the GSHGPX4 ferroptosis pathway

Since rheumatoid arthritis is an autoimmune disease meaning the body is working against itself many of the treatment options can seem limited to pain reduction, rather than helping the body get its immune balance back in shape

Jelovac N1, Sikiric P, Rucman R, Petek M, Marovic A, Perovic D, Seiwerth S, Mise S, Turkovic B, Dodig G, Miklic P, Buljat G, Prkacin I J Orthop Res

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Elevated circulating cytokines, chemokines, and inflammasome activation reflect a primed immune state correlated with disease progression, whereas metabolic disturbances in tryptophan, purine, lipid, and microbiota-derived pathways connect peripheral metabolic imbalance to neuronal vulnerability