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HCT-116 cells were pre-incubated with NAC (5 mM) for 12 h, followed by treatment with HMF (100 M) for 24 h

however, high elevated NADH levels can inhibit the entry of acetyl-CoA into the tricarboxylic acid (TCA) cycle by shifting metabolic flux toward ketogenesis

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Overall, about 13.5% of adults aged 40 and older are affected (Hicks et al., 2021)

M1 macrophages are dominated by fatty acid synthesis, with significantly reduced FAO activity

Holmgreen A: Pyridine-nucleotide-disulfide oxidorreductases