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Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al

Utility of circulating tumor DNA in the clinical management of patients with BRAFV600E metastatic colorectal cancer

Its underlying principle is to connect the specific functional groups of metabolites, needed to be analyzed, with chemical derivatization reagents to enhance their stability and ionization efficiency, making them more suitable for chromatographic analysis [100]