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Interest in allopurinol re-emerged in 1965 when it was recognised that it could be used to reduce uric acid levels in patients with gout and tumour related hyperuricemia [20, 26]

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FIGURE 1 Glutamate-storage, uptake and recycling Glu, glutamine (Gln) and cysteine play vital roles in ferroptosis

Martn M, Macas M, Len J et al (2002) Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria