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Despite these differences, convergent functional outcomes have been reported, such as restoration of follicle numbers, normalization of estrous cyclicity and hormone profiles, reduced granulosa cell apoptosis, and improved ovarian architecture, frequently associated with activation of pathways including PI3K/AKT or SMAD signaling (He et al., 2024, Huang et al., 2018, Yang et al., 2019)

These findings highlight the role of metformin-modulated microbiota in protecting against ferroptosis and supporting intestinal barrier function in IIRI

Rinse thoroughly with clean water and pat dry

(2021) described some of the actions and mechanisms of these molecules in autophagy: treatment with MPTP/MPP + promotes autophagy initiation but blocks autophagic flux, probably by activating AMPK and ERK while reducing mTOR and lysosomal hydrolase activity

Moreover, the regulation of plasticity extends beyond synaptic plasticity alone and should also encompass broader regulatory effects on neuronal function and structural plasticity ( Table 5 )

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